Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1 in human bronchial epithelia
نویسندگان
چکیده
Thomas Gray,* Ray Coakley,* Andrew Hirsh, David Thornton, S. Kirkham, Ja-Seok Koo, Lauranell Burch, Richard Boucher, and Paul Nettesheim Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park 27709; Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599-7248; Department of Thoracic/Head & Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; and Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, United Kingdom
منابع مشابه
Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia.
Mucociliary transport in the airways significantly depends on the liquid and mucin components of the airway surface liquid (ASL). The regulation of ASL water and mucin content during pathological conditions is not well understood. We hypothesized that airway epithelial mucin production and liquid transport are regulated in response to inflammatory stimuli and tested this hypothesis by investiga...
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